Organometallic Compounds
Medchemexpress LLC Methoxy-PEG3 tosylate | 62921-74-8 | MFCD13184964 | 98.8% | 318.39 g/mol | C14H22O6S | 250 MG
m-PEG3-Tos is a methoxy-terminated PEG3 tosylate used as a short, flexible PEG linker and intermediate in small-molecule synthesis. It provides three ethylene glycol units with a tosylate leaving group, making it suitable for nucleophilic substitution to install PEG chains and build PROTAC linkers or other conjugates.
- Provides three ethylene glycol units for short, flexible spacing.
- Contains a tosylate leaving group suitable for nucleophilic substitution.
- High purity (98.75%) appropriate for synthetic applications.
- Available in small-scale quantities for research use, such as 250 mg.
Medchemexpress LLC m-PEG5-NH2 | 5498-83-9 | 99.0% | C11H25NO5 | 250 MG
m-PEG5-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules consisting of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These molecules function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only and not sold to patients.
- Purity: 99.02%
- Molecular weight: 251.32
- Formula: C11H25NO5
- CAS number: 5498-83-9
- Appearance: Liquid (density: 1.023±0.06 g/cm³)
- Color: Colorless to light yellow
- SMILES: COCCOCCOCCOCCOCCN
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Azido-PEG5-CH2CO2H | 217180-81-9 | 98.9% | 321.33 g/mol | C12H23N3O7 | 250 MG
Azido-PEG5-CH2CO2H is a cleavable, azide-functionalized polyethylene glycol (PEG) linker with a terminal carboxylic acid that provides a hydrophilic spacer and a reactive azide handle for bioconjugation and linker synthesis.
- Cleavable 5-unit PEG linker suitable for linker-based conjugation.
- Azide functional group for copper-catalyzed or strain-promoted click reactions.
- Terminal carboxylic acid enables further derivatization or coupling.
- Hydrophilic spacer increases solubility in aqueous media.
- High purity suitable for chemical synthesis and bioconjugation.
- Available in 250 MG pack size.
Medchemexpress LLC BCN-exo-PEG3-NH2 | 1841134-72-2 | >95.0% | C19H32N2O5 | 10MG
BCN-exo-PEG3-NH2 is a BCN-functionalized PEG3 amine linker used in bioorthogonal conjugation and PROTAC linker synthesis. It provides a strained alkyne handle and a terminal primary amine to enable modular coupling strategies, and is commonly supplied in research-scale quantities at high reported purity.
- Provides a strained alkyne (BCN) for rapid bioorthogonal click reactions.
- Contains a PEG3 spacer for flexibility and improved solubility.
- Features a terminal primary amine for amide or reductive amination conjugation.
- Suitable for linker construction in targeted degradation and bioconjugation workflows.
- Supplied in research-scale quantities with supplier-reported high purity.
Medchemexpress LLC NH2-PEG5-C6-Cl hydrochloride | 2241669-16-7 | 98.0% | 1 G
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Applicable in cancer and cancer targeted therapy research
- Classified as PROTAC linkers
Medchemexpress LLC DBCO-S-S-PEG3-biotin | 1430408-09-5 | 96.9% | 869.12 | 25 MG
DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Azido-PEG5-azide | 356046-26-9 | 99.98% | 332.36 | 500 MG
Azido-PEG5-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
- For research use only
Medchemexpress LLC 5,8,11-Trioxa-2,14-diazahexadecanoic acid, 16-bromo-15-oxo-, 1,1-dimethylethyl ester | 1421933-39-2 | ≥98.0% | C15H29BrN2O6 | 500 MG
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by utilizing the ubiquitin-proteasome system, connecting ligands for an E3 ubiquitin ligase and the target protein via a linker.
- Suitable for PROTAC synthesis
- Utilizes PEG-based linker technology
- Facilitates targeted protein degradation
Medchemexpress LLC 1,11-Bis-maleimidotetraethyleneglycol | 86099-06-1 | 98.0% | 250 MG
BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands
- One ligand for E3 ubiquitin ligase
- Other ligand for target protein
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC M-PEG3-succinimidyl carbonate | 477775-77-2 | 99.4% | C12H19NO8 | 250 MG
m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein. These molecules function by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Tos-PEG3 | 77544-68-4 | 97.0% | 304.36 | 50 G
Tos-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It can also be utilized for the synthesis of 3'-aminooxy oligonucleotides solid supports.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Can be utilized for the synthesis of 3'-aminooxy oligonucleotides solid supports
CCOCCOCCOC)(OCC)OCC | 1g | 411413983](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183471.JPG-250.jpg)
eMolecules 2243566-45-0 | m-PEG3-triethoxysilane | Broadpharm395.568 | C17H37NO7Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOC)(OCC)OCC | 1g | 411413983
m-PEG3-triethoxysilane | Broadpharm | 2243566-45-0395.568 | C17H37NO7Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOC)(OCC)OCC | 1g | 411413983
Medchemexpress LLC BM-PEG3 | 86099-06-1 | 98.0% | 100 MG
BM-PEG3 is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, enabling targeted degradation.
- PEG-based PROTAC linker
- For research use only
- Purity: 98.0%
- Molecular weight: 352.34
- Molecular formula: C16H20N2O7
- Appearance: White to light yellow solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 100 mg/mL (in vitro)
- Solubility in 10% DMSO, 90% corn oil: ≥ 2.5 mg/mL (in vivo)
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 hydrochloride | 2446474-09-3 | 96.6% | 25 MG
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates the Pomalidomide based cereblon ligand
- Utilizes a 3-unit PEG linker
- Used in PROTAC technology
- Targets E3 Ligase Ligand-Linker Conjugates
- Pathway is PROTAC
- IC50 & Target is Cereblon
Medchemexpress LLC 2,5,8,11,14-Pentaoxahexadecane, 16-bromo- | 854601-80-2 | 98.0% | C11H23BrO5 | 1 G
m-PEG5-Br is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins